Genetics of HIV-1infection: chemokine receptor CCR5 polymorphism and its consequences
نویسندگان
چکیده
منابع مشابه
Host genes and HIV: the role of the chemokine receptor gene CCR5 and its allele.
Since the late 1970s, 8.4 million people worldwide, including 1.7 million children, have died of AIDS, and an estimated 22 million people are infected with human immunodeficiency virus (HIV)(1). During 1995 and 1996, major clinical and laboratory discoveries regarding HIV pathogenesis provided new hope for the prevention and treatment of HIV infection. One major discovery was that members of th...
متن کاملHost Genes and HIV: The Role of the Chemokine Receptor Gene CCR5 and Its Allele (∆32 CCR5)
The HIV Epidemic: a Global Problem The World Health Organization has estimated that 22.6 million people are infected with human immunodeficiency virus (HIV) as of mid-1996 (1). The highest prevalence of HIV occurs in parts of Asia and sub-Saharan Africa. In 1995, HIVassociated illnesses caused the deaths of 1.3 million people, including 300,000 children under 5 years of age. No protective vacci...
متن کاملEffects of CC chemokine receptor 5 (CCR5) inhibitors on the dynamics of CCR5 and CC-chemokine-CCR5 interactions.
BACKGROUND This study aimed to examine how CC chemokine receptor 5 (CCR5) inhibitors (aplaviroc [APL], TAK779 and maraviroc [MVC]) interact with CCR5 and affect its dynamics and physiological CC-chemokine-CCR5 interactions. METHODS A yellow fluorescent protein (YFP)-tagged CCR5-expressing U373-MAGI cell line was generated and a stable CCR5-expressing clonal population, (YFP)CCR5-UM16, was pre...
متن کاملa study of cc-chemokine receptor 5 (ccr5) polymorphism on the outcome of hcv therapy in egyptian patients
conclusions snps within the ccr5 gene should be considered as an important factor used in combination with other host gene snps when developing a mathematical model for anticipating response to hcv therapy. background chronic hepatitis c virus (hcv) infection is a globally serious public health issue. objectives in this study, we investigated cc chemokine receptor 5 (ccr5-59029) polymorphism wh...
متن کاملCONCISE REPORT Evidence for negative association of the chemokine receptor CCR5 d32 polymorphism with rheumatoid arthritis
Background: Ligands of chemokine receptor CCR5, including MIP-1a, MIP-1b, and RANTES, have been implicated in rheumatoid arthritis. Objective: To test whether CCR5 d32 polymorphism has a negative association with rheumatoid arthritis in a New Zealand cohort. Methods: 516 white patients with rheumatoid arthritis and 985 healthy controls were investigated by PCR amplification of the region flanki...
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ژورنال
عنوان ژورنال: Human Molecular Genetics
سال: 1999
ISSN: 1460-2083
DOI: 10.1093/hmg/8.10.1939